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Endometrial dating pathology

endometrial dating pathology-36

It is asserted that examination of the endometrium during the secretory phase yields more information about the time of ovulation, degree of progestational change, and normality of the endometrium than any other test used in sterility studies.Attention to qualitative changes in 8 morphological factors is most useful in dating the endometrial biopsy.

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Postovulatory phase (secretory phase) endometrial dating has become the standard and is usually reported within a 2-day range, although the accuracy of this dating methodology is the subject of some debate.In addition, the original description fixed the time of ovulation with the onset of the period after the biopsy.The onset of ovulation can be more accurately determined using current modalities, such as determination of the midcycle urinary luteinizing hormone surge or ultrasonic identification of the collapse of a follicle.However, the accuracy of this test has been questioned because abnormal results can be observed in cycles that eventually prove to result in a viable pregnancy.Endometrial dating can be performed both before and after ovulation.Of the 40 patients who had adequate temperature records, 31 (78%) ovulated as predicted allowing a or- 1 day error, indicating that dating is a better gauge of duration of progesterone effect than predictor of onset of menses.

To determine whether biopsy caused early menstruation, the secretory phases of the 25 patients who had recorded temperatures in at least 2 cycles in addition to that in which the biopsy was taken were examined.

The endometrium is functionally divided into two layers: the basalis and the functionalis. The stroma is composed of stromal cells, vessels, and white blood cells thought to be lymphocytes or macrophages.

Cyclic changes occur in both endometrial glands and stroma in response to a changing endocrine environment.

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Please see TOPA Diagnostics can process any specimen, including but not limited to: Surgical Pathology Bone marrow aspiration and core biopsy Lymph node biopsy Lymph node excisional biopsy Splenectomy Skin Biopsy Soft tissue/bone biopsy/excision Solid tumor biopsy/excision Full range of immunohistochemical stains for diagnosis and prognosis Full range of special stains for microorganisms Cytology Bone marrow aspiration smears Peripheral blood smears Lymph node fine needle aspirations Fine needle aspirations Cyst fluid Body fluid Molecular/Ancillary/Prognostic Testing FISH for myelodysplasia, lymphoma, leukemia, myeloma Flow cytometry on peripheral blood Flow cytometry on bone marrow aspirations Cytogenetics on all bone marrow cases EGFR, ALK, Ros1 testing on all lung adenocarcinomas LYNCH Syndrome/Microsatellite instability testing onall colorectal cancers RAS testing on all metastatic colorectal cancers BRAF testing on all metastatic melanoma cases her2, ER, PR, Ki-67, p53 on all breast carcinoma cases her2 testing on all gastric cancers p16 testing for HPV on all head and neck squamous cell carcinomas Next Generation Sequencing Microbiology cultures (complimentary send out program)TOPA Diagnostics can process any specimen, including but not limited to: Surgical Pathology Cervical biopsy Endocervical curettage Endometrial biopsy (including evaluation for endometritis and endometrial dating) Endometrial curettage Vulvar biopsy Skin biopsy Breast biopsy Products of conception (including cytogenetics) Cytology Pap smear Nipple Discharge Urine cytology Fine Needle Aspirations Molecular Testing All tests are performed using FDA Approved molecular technologies HPV testing of high-risk strains and genotyping of 16 * 18 Chlamydia Gonorrhea Affirm Tests (Candida, Gardnerella, Trichomonas) Pertussis Group A Strep Influenza (Flu A, B, & H1N1-2009 Strain) GI Rapid Molecular Microbiology Panel C.

An appreciation of the relationship between form and function is important for understanding of female reproduction.